Immunization withStaphylococcus aureusiron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model
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Immunization with Staphylococcus aureus iron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model
We have previously shown that IsdB, a conserved protein expressed by Staphylococcus aureus, induces a robust antibody response which correlates with protection in a murine challenge model. Here we investigate the role of cellular immunity in IsdB mediated protection using lymphocyte deficient SCID mice. As opposed to WT CB-17 mice the CB-17 SCID mice were not protected against a lethal challeng...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2012
ISSN: 2164-5515,2164-554X
DOI: 10.4161/hv.18946